| 摘要 |
PURPOSE:To provide the subject preparation capable of surely transporting Bifidobacterium bacteria to a small intestine without killing the bacteria in a stomach when the preparation is orally administered, and resisting to the storage thereof for long periods. CONSTITUTION:A Bifidobacterium bacterium preparation comprises the powder of Bifidobacterium bacteria coated with an enteric coating material such as carboxymethyl cellulose or shellac. The Bifidobacterium bacterium preparation is produced by dissolving or dispersing an enteric coating material in a solvent, dispersing the powder of the Bifidobacterium bacterium cells in the solution or dispersion, and subsequently spray-drying the obtained dispersion; or dissolving or dispersing the enteric coating material in a solvent, feeding the solution or dispersion into a high speed gas flow, bringing the fed solution or dispersion into contact with the powder of the Bifidobacterium bacterium cells fed into the high speed gas flow to coat the powder of the bacterium cells with the enteric coating material, and subsequently drying the coated powder. |
