| 发明名称 |
USE OF FOLIC ACID AND ITS DERIVATIVES FOR REDUCING THE TOXICITY OF GAR-TRANSFORMYLASE INHIBITORS |
| 摘要 |
Administration of a folate binding protein binding agent in conjunction with use of an antitumor agent which is an inhibitor of glycinamide ribonucleotide transformylase or other antifolate reduces the toxic effects of such agent and provides an enhanced therapeutic index.
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| 申请公布号 |
CA2051520(A1) |
申请公布日期 |
1992.09.30 |
| 申请号 |
CA19912051520 |
申请日期 |
1991.09.17 |
| 申请人 |
LILLY (ELI) AND COMPANY |
发明人 |
GRINDEY, GERALD B.;SHIH, CHUAN |
| 分类号 |
A61K31/505;A61K31/519;A61K31/525;A61K45/00;A61P35/00;A61P43/00;C07D471/04;(IPC1-7):A61K31/505 |
主分类号 |
A61K31/505 |
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代理人 |
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