摘要 |
2107219 9217445 PCTABS00016 S-nitrosothiols exert a potent relaxant effect, mediated by guanylate cyclase, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols may be used for the treatment or prevention of disorders associated with relaxation of smooth muscle, such as airway obstruction, and other respiratory disorders, bladder dysfunction, premature labor and impotence. Additionally, S-nitrosothiols may be used to alleviate smooth muscle contraction and spasm, and thus facilitate procedures involving diagnostic instrumentation, such as endoscopy, bronchoscopy, laparoscopy and cystoscopy.
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申请人 |
BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
STAMLER, JONATHAN S.;LOSCALZO, JOSEPH;SLIVKA, ADAM;SIMON, DANIEL;BROWN, ROBERT;DRAZEN, JEFFREY |