PHARMACEUTICALLY ACTIVE CONJUGATES HAVING IMPROVED BODY TISSUE BINDING SPECIFICITY

摘要

PCT No. PCT/GB87/00854 Sec. 371 Date Jul. 21, 1989 Sec. 102(e) Date Jul. 21, 1989 PCT Filed Nov. 27, 1987 PCT Pub. No. WO88/03810 PCT Pub. Date Jun. 2, 1988.Pharmaceutically active conjugates comprising a pharmaceutically active substance for treating a disorder of the body that involves a specified body tissue conjugated directly or indirectly with at least one fragment of an adhesive glycoprotein such as fibronectin, the said glycoprotein fragment(s) having improved binding specificity compared with the parent protein for the said body tissue.