| 摘要 |
PCT No. PCT/DE90/00690 Sec. 371 Date Jun. 22, 1991 Sec. 102(e) Date Jun. 22, 1991 PCT Filed Sep. 6, 1990 PCT Pub. No. WO91/04264 PCT Pub. Date Apr. 4, 1991.A process for the production of 3-hydroxy-1,3,5(10)-estratrien-17-one by pyrolysis of 1,4-androstadiene-3,17-dione in the presence of 1,2,3,4-tetrahydronaphthalene as hydrogen donor is described, by 1,2,3,4-tetrahydronaphthalene, preheated to a temperature of 450 DEG -850 DEG C., in a mixing zone being mixed with a solution, heated to a temperature of up to 300 DEG C., of 1,4-androstadiene-3,17-dione, in 1,2,3,4-tetrahydronaphthalene, the mixture being heated in a pyrolysis zone at a retention time of 0.001 to 60 seconds to temperatures of 450 DEG -700 DEG C. and the product leaving the pyrolysis zone being cooled off, which is characterized in that the pyrolysis is performed under a pressure of 3.5x106 to 3x108 Pa.
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