CHIMAERIC ANTIBODIES CONTAINING THE LIGAND DOMAIN OF CD4

摘要

RAN 4105/139 The present invention relates to a DNA sequence comprising two DNA subsequences, each subsequence-independently from the other one-coding for a ligand binding site of 2 human receptor, an antigen binding site or a ligand of a human receptor and optionally further comprising a third DNA subsequence coding for the constant domain or parts thereof of a human immunglobulin ?or .lambda.-light chain, to vectors containing such DNA sequences, to prokaryotic or eukaryotic host cells transformed with such vectors, to polypeptides encoded by such DNA sequences, to a method for the production of such polypeptides, to pharmaceutical compositions containing such polypeptides and to the use of such polypeptides for the preparation of pharmaceutical compositions, especially compositions for the treatment of AIDS and the use of such polypeptides for the treatment of deseases, especially AIDS.