发明名称 |
PROCESS FOR PRODUCING SUBSTITUTED INDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS |
摘要 |
<p>The present invention relates to novel indole derivatives of the formula : <CHEM> wherein R<1> is carboxy or protected carboxy, R<2> is hydrogen, lower alkyl or halogen, R<3> is aryl or ar(lower)alkyl, each of which may have suitable substituent(s), or a group of the formula : <CHEM> A is lower alkylene which may be substituted by oxo or lower alkenylene, Q is carbonyl or lower alkylene, X is <CHEM> or <CHEM> in which R<4> is hydrogen or lower alkyl, and R<5> is hydrogen, lower alkyl or Y-Z-R<3>, Y is bond or lower alkylene, Z is lower alkylene, -O- or <CHEM> in which R<6> is hydrogen, lower alkyl, ar(lower)alkyl which may have suitable substituent(s) or amino protective group, and pharmaceutically acceptable salts thereof, which have pharmacological activities such as inhibitory activity on testosteron 5 alpha -reductase and the like, to process for preparation thereof, to a pharmaceutical composition comprising the same and to a use of the same for manufacturing a medicament.</p> |
申请公布号 |
HUT60471(A) |
申请公布日期 |
1992.09.28 |
申请号 |
HU19910001681 |
申请日期 |
1991.05.20 |
申请人 |
FUJISAWA PHARMACEUTICAL CO. LTD.,JP |
发明人 |
OKADA,SATOSHI,JP;SAWADA,KOZO,JP;KAYAKIRI,NATSUKO,JP;SAITOH,YUKI,JP;TANAKA,HIROKAZU,JP;HASHIMOTO,MASASHI,JP |
分类号 |
A61K31/40;A61K31/403;A61K31/404;A61K31/55;A61P13/02;A61P15/00;A61P17/00;A61P43/00;C07D209/04;C07D209/12;C07D209/14;C07D209/18;C07D209/30;C07D403/10;C07D405/06;C07D413/10;C07D417/10;(IPC1-7):C07D209/12;A61K31/475 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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