Stimulating factor of the neu receptor.

摘要

The neu proto-oncogene encodes a transmembrane glycoprotein related to the receptor for epidermal growth factor (EGF). Purification of a stimulating factor for the neu receptor to homogeneity from ras-transformed fibroblasts has now been achieved. Its identity as a neu receptor stimulating factor has been established by covalent crosslinking experiments. The factor stimulates the tyrosine phosphorylation of the neu receptor at low concentrations. The factor inhibits the proliferation and promotes the differentiation of human carcinoma cells.