发明名称 |
1,2,4-Oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity and method for preparing same. |
摘要 |
<p>A 1,2,4-oxadiazole derivative is represented by the following general formula (I): <CHEM> wherein R<1> represents a lower alkyl or cycloalkyl group, a lower alkyl group substituted with a halogen atom, a lower alkylamino group or a phenyl group; R<2> represents a hydrogen atom, a lower dialkylamino group, a cyclic alkylamino group, a cyclic amino group having an oxygen or nitrogen atom in the ring, a phenyl group which may be substituted with a halogen atom, a pyridyl group, an imidazolyl group, an alkylimidazolyl group, a benzimidazolyl group or a 2-oxopyrrodinyl group; and n is 1, 2 or 3. The derivative has excellent monoamine oxidase-inhibitory activity and is effective as a medicine for treating Parkinson's disease.</p> |
申请公布号 |
EP0504574(A1) |
申请公布日期 |
1992.09.23 |
申请号 |
EP19920101983 |
申请日期 |
1992.02.06 |
申请人 |
WAKAMOTO PHARMACEUTICAL CO., LTD. |
发明人 |
TOYOFUKU, HATSUNORI;MATSUMOTO, JUN;TAKAHASHI, TOSHIE;EBIE, MASAKAZU;SASADA, NAOMI;MITSUZI, AGATA;SHOHEI, SAWAKI;MASAYOSHI, GOTO |
分类号 |
A61K31/41;A61K31/4245;A61K31/44;A61K31/445;A61K31/495;A61K31/496;A61K31/535;A61K31/5377;A61P25/00;C07D271/06;C07D413/12;C07D521/00;C12N9/99 |
主分类号 |
A61K31/41 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|