INSULIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM

摘要

The invention relates to insulin derivatives of the formula III <IMAGE> (III) in which R30 and R31 together are OH, or R30 is a radical of a neutral, genetically encodable L-amino acid and R31 is OH or a physiologically acceptable organic group of basic character having up to 50 carbon atoms, whose synthesis involves 0 to 3 alpha -amino acids and whose optional terminal carboxyl function can be present free, as an ester function, as an amide function, as a lactone or reduced to CH2OH, and RA-1 is a radical of a genetically encodable L-amino acid, and physiologically acceptable salts of said insulin derivative of the formula III.