| 摘要 |
<p>Benzoheterocyclylalkylaminoalkanediphosphonic acids of formula I <IMAGE> (I) wherein R1 and R2, independently of one another, are hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, R3 is hydrogen or lower alkyl, X and Y, independently of one another, are oxy or thio, alk1 and alk2 are identical or different lower alkylene radicals, n is 0 or 1 and m and m', independently of one another, are 0, 1 or 2, the sum of n, m and m' being 1, 2 or 3, and their salts exhibit a pronounced regulatory action on the calcium metabolism of warm-blooded animals. They are prepared, for example, as follows: in a compound of the formula <IMAGE> (II) wherein R1, R2, n, m, m', X, Y, alk1 and alk2 are as defined above, R'3 is one of the groups R3 mentioned above or is an amino-protecting group R0, Z1 is a functionally modified phosphono group, and Z2 is a free or functionally modified phosphono group, converting functionally modified phosphono Z1 and, where appropriate, Z2 into the free phosphono group, and, if desired, converting a resulting compound into a different compound of formula I, separating a mixture of isomers obtainable in accordance with the process into the components and separating the preferred isomer, and/or converting a free compound obtainable in accordance with the process into a salt or converting a salt obtainable in accordance with the process into the corresponding free compound.</p> |
