1-Biphenylimidazole derivatives, their preparation and their therapeutic use.

摘要

Compounds of formula (I): in which: R<1> is alkyl or alkenyl; R<2> and R<3> are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R<4> is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula -SiRRR, in which R, R and R are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R<5> is carboxy or a group of formula -CONR<8>R<9>, in which R<8> and R<9> are hydrogen atoms or alkyl, or R<8> and R<9> together form alkylene; R<6> is hydrogen, alkyl, alkoxy or halogen; R<7> is carboxy or tetrazol-5-yl; and pharmaceutically acceptable salts and esters thereof have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. They may be prepared, inter alia, by reacting a biphenylmethyl compound with an imidazole compound.