发明名称 METHOD FOR THE PREPARATION OF METHACRYLIC AND ACRYLIC CO- POLYMER WATER SUSPENSIONS
摘要 This method is used in the pharmaceutical industry. It enables the derivation of concentrated and stable water suspensions, practically without any coagulate, with small mean size of the disperse particles (between 60 and 140 nanometres), narrow allocation of the same, as well as co-polymers with larger and regulated molecular mass, whose films are elastic, strong and may be used for medical pills coating. The method entails the continual adding of co-monomeric mixture to the surface substance - nonylphenol polyglycol ether, ethoxylated with 10 moles of ethylene oxide - for 4-6 hours, heated to 75-80 degrees C, and saturated with gaseous nitrogen, also containing the substance dodecylbenzol sulphonic c acid. The addition of the initiator - ammonium per sulphate - is carried out in 5-6 equal portions for 1-1.5 hours, with the inclusion of the monomeric mixture of 2-hydroxy ethyl methacrylate or diethylene glycol methacrylate, or diethylene glycol acrylate, or their mixture. The emulsion's co-polymerisation continues for about 10 hours and is considered complete after the residual monomers become less than 0.3%. The derived suspension may be used as a film-forming material.
申请公布号 BG50594(A3) 申请公布日期 1992.09.15
申请号 BG19910094572 申请日期 1991.06.04
申请人 SOFIJSKI UNIVERSITET SV.KLIMENT OKHRIDSKI 发明人 ILIEV, STEFAN B.;GEORGIEV, GEORGI S.
分类号 A61K9/32;C08F120/10;(IPC1-7):A61K9/32 主分类号 A61K9/32
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