VECTORS AND EXPRESSION SEQUENCES FOR PRODUCTION OF POLYPEPTIDES

摘要

X-7336 The present invention is composed of novel recombinant DNA expression vectors which contain a transcriptional activating sequence, a DNA sequence selected from the group as set forth below 1) 2) 3) 4) X-7336 5) 6) 7) 8) and a DNA sequence coding for a bioactive polypeptide, especially bovine growth hormone. The aforementioned sequences contain a ribosome binding site and are designed to provide high level expression of DNA that codes for virtually any bioactive polypeptide. The invention further provides transformed microbial host cells capable of producing bovine growth hormone and other bioactive polypeptides at high levels.