Polypeptides with fibronectin activity

摘要

A composition which can bind heparin and promote cellular adhesion and neurite outgrowth is provided which consists essentially of a polypeptide of the formula: tyr-glu-lys-pro-gly-ser-pro-pro-arg-glu-val-val-pro-arg-pro-arg-pro-gl y-val, lys-asn-asn-gln-lys-ser-glu-pro-leu-ileu-gly-arg-lys-lys-thr-asp-glu-leu, or mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with the polypeptide composition are also provided.