PREPARATION OF NITRATOALKYL-SUBSTITUTED CYCLIC ESTERS

摘要

PCT No. PCT/GB89/00812 Sec. 371 Date Mar. 22, 1991 Sec. 102(e) Date Mar. 22, 1991 PCT Filed Jul. 14, 1989 PCT Pub. No. WO90/01028 PCT Pub. Date Feb. 8, 1990.A continuous process for producing nitratoalkyl-substituted cyclic ethers which consists of (a) cocurrently mixing a stream of N2O5 and a stream of a hydroxyalkyl-substituted cyclic ether each dissolved in an inert organic solvent, followed by (b) rapidly separating the nitric acid and nitratoalkyl coproducts before they can react together to rupture the ether ring. Step (b) is conveniently performed by quenching the product stream within approximately 15 seconds of its formation, in a basic aqueous solution into which the nitric acid is transferred from the organic phase and is neutralized. Examples of products which may be prepared by this process are nitratoalkyl-substituted oxiranes and oxetanes.