Substituted cyclic sulphamide derivatives.

摘要

Compounds of formula I, or a salt or prodrug thereof: <CHEM> wherein -X- represents -(CH2)m- in which m is 2 or 3; A<1> represents hydrogen, hydrocarbon or a heterocyclic group; A<2> and A<3> independently represent hydrogen or c1-6 alkyl; E represents a bond or a straight or branched alkylene chain containg from 1 to 4 carbon atoms; and F represents a group of formula <CHEM> in which U represents nitrogen or C-R<2>; V represents oxygen, sulphur or N-R<3>; R<1> represents -(CH2)pCHR<4>.NR<6>R<7> or a group of formula <CHEM> in which the broken line represents an optional chemical bond; p is 1 or 2; and R<2>, R<3>, R<4>, R<5>, R<6> and R<7> independently represent hydrogen or C1-6 alkyl. The derivatives are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.