| 发明名称 |
Naphthalene lactones as inhibitors of leukotriene biosynthesis. |
| 摘要 |
<p>Compounds having the formula I: <CHEM> are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.</p> |
| 申请公布号 |
EP0501579(A1) |
申请公布日期 |
1992.09.02 |
| 申请号 |
EP19920200520 |
申请日期 |
1992.02.22 |
| 申请人 |
MERCK FROSST CANADA INC. |
发明人 |
YOUNG, ROBERT N.;TRIMBLE, LAIRD A.;GILLARD, JOHN W.;SCHEIGETZ, JOHN;GIRARD, YVES;DUCHARME, YVES;YERGEY, JAMES A.;NICOLL-GRIFFITH, DEBORAH A.;HUTCHINSON, JOHN H. |
| 分类号 |
A61K31/34;A61K31/343;A61K31/35;A61K31/352;A61K31/4433;A61K31/445;A61K31/535;A61K31/54;A61P9/00;A61P11/00;A61P17/00;A61P25/04;A61P27/16;A61P37/06;A61P37/08;C07D307/92;C07D311/92;C07D407/12;C07D409/12;C07D493/08 |
主分类号 |
A61K31/34 |
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