发明名称 |
Method of producing D-ribose. |
摘要 |
Disclosed are (1) a method of producing D-ribose which comprises cultivating a microorganism belonging to the genus Bacillus having D-ribose producing ability in a medium, the microorganism belonging to the genus Bacillus containing a DNA sequence participating in expression of a gluconate operon which is partly or wholly modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus, accumulating D-ribose, and collecting D-ribose thus obtained; (2) a novel microorganism belonging to the genus Bacillus having D-ribose producing ability transformed with DNA which contains a DNA sequence participating in expression of a gluconate operon which is partly or wholly modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus; (3) novel DNA in which a promoter of a gluconate operon of a microorganism belonging to the genus Bacillus is modified so as to highly express said gluconate operon in the microorganism belonging to the genus Bacillus; and (4) a novel vector into which DNA is introduced in which a promoter of a gluconate operon of a microorganism belonging to the genus Bacillus is modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus, whereby D-ribose can be produced in stable form in large amounts. |
申请公布号 |
EP0501765(A1) |
申请公布日期 |
1992.09.02 |
申请号 |
EP19920301596 |
申请日期 |
1992.02.26 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
MIYAGAWA, KENICHIRO;MIYAZAKI, JUNICHI;KANZAKI, NAOYUKI |
分类号 |
C12N1/21;C12N9/12;C12N15/09;C12N15/52;C12N15/54;C12N15/75;C12P19/02;C12R1/125 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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