发明名称 |
NEW MACROCYCLIC NITROGEN LIGANDS, METHOD FOR THEIR PREPARATION, METAL COMPLEXES, DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS |
摘要 |
Ligands of formula <IMAGE> in which B represents a group <IMAGE> W represents the group <IMAGE> in which x and Z represent a heterocycle. An additional subject of the invention is the mono- or polymetallic complexes formed by these ligands with metal ions chosen from lanthanide ions, transition metal ions, barium, bismuth, lead and the radioisotopes <99m>Tc, <111>In, <90>Y, <64>Cu and <169>Yb, as well as the physiologically acceptable salts of these complexes. The salts of these complexes can be used as diagnostic and therapeutic agents in magnetic resonance imaging, X-ray radiology, as in vivo chemical displacement agents and in nuclear medicine. |
申请公布号 |
EP0499501(A3) |
申请公布日期 |
1992.08.26 |
申请号 |
EP19920400174 |
申请日期 |
1992.01.22 |
申请人 |
GUERBET S.A. |
发明人 |
ROUSSEAUX, OLIVIER;SCHAEFER, MICHEL;BOUILLOT, ANNE;MEYER, DOMINIQUE |
分类号 |
A61K49/00;A61K49/04;A61K51/00;A61K51/04;C07D;C07D401/06;C07D403/06;C07D405/04;C07D405/06;C07D493/04;C07F9/6558;(IPC1-7):C07D405/06;A61K43/00;A61K49/02;C07F9/655 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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