发明名称 |
AVIRULENT MICROBES AND USES THEREFOR:SALMONELLA TYPHI |
摘要 |
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition. |
申请公布号 |
ZA9108876(B) |
申请公布日期 |
1992.08.26 |
申请号 |
ZA19910008876 |
申请日期 |
1991.11.08 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
ROY CURTISS III;SANDRA M. KELLY |
分类号 |
C12N15/09;A61K39/00;A61K39/112;A61P31/04;A61P37/04;C07K14/255;C12N1/21;C12N5/10;C12N15/00;C12N15/01;C12R1/01 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|