发明名称 |
METHOD OF PREPARATION OF PILOCARPINES AND INTERMEDIATES THEREOF |
摘要 |
2101445 9214693 PCTABS00015 Synthesis of (+)-pilocarpine is achieved via homochiral monoprotected propane-1,3-diols prepared in > 98 % e.e. by enzyme catalyzed acylation of the corresponding diol, and lactones derived therefrom, or via acetylenic alcohols which upon imidazolisation and catalysed carbonylation are converted to lactones again leading to pilocarpine and analogues thereof.
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申请公布号 |
CA2101445(A1) |
申请公布日期 |
1992.08.26 |
申请号 |
CA19922101445 |
申请日期 |
1992.02.17 |
申请人 |
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发明人 |
DAVIES, STEPHEN G.;STEPHENSON, PETER T. |
分类号 |
A61K31/365;A61K31/357;C07C43/315;C07C69/003;C07C69/16;C07C69/63;C07D307/33;C07D319/06;C07D405/06;C07F7/18;C12P7/62;C12P41/00;(IPC1-7):C12P7/62;C12P17/02;C07D321/06;C07D407/06;C07D317/24;A61K31/415 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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