CARDIAC VULNERABILITY TRACKING BY T-WAVE ALTERNANS ANALYSIS

摘要

2104450 9214401 PCTABS00015 A method for dynamic tracking of cardiac vulnerability to ventricular fibrillation is disclosed. A heart is monitored to sense an ECG signal (202) which is amplified (206) and low-pass filtered (208) before it is digitally sampled (210) and stored (212). The location of the T-wave in each R-R interval of the ECG is estimated and each T-wave is partitioned into a plurality of time divisions. The sampled ECG signal in each of the time divisions is summed together and a time series is formed for each of the time divisions such that each time series includes corresponding sums from corresponding time divisions from successive T-waves. Each time series is detrended in order to eliminate the effects of drift and DC bias, and then a method of dynamic estimation is performed on each time series to estimate the amplitude of alternation for each time division (214).