VERFAHREN ZUR HERSTELLUNG VON 6-AMINOCAPRONSAEUREESTERN.

摘要

Esters of 6-aminocaproic acid are prepd. by reacting esters of 5-formyl-valeric acid with NH3 and H2, with alcohols as solvents, in presence of hydrogenation catalysts under increased pressure and at 40-95 deg. C. Pref. the catalyst is (i) prepd. by calcination of: ((MgaNi(II)bCo(II)cAl2)CO3(OH)16.4H2O at 200-600 deg. C, followed by redn. with H2 at raised temp., or (ii) 30-60 wt.% of finely divided Ni pptd. on Mg silicate. In the formulae, a = 0-4; b, c = 0-6; 2 x (a+b+c) = 12. Pref. alkanol solns. of 5-formyl valeric acid esters are led with NH3 over a fixed bed catalyst. Raney Ni or Raney Co may be used in a suspension process, opt. fixed in the reaction zone (electro)-magnetically. The catalyst is 0.2-2 kg of 5-formylvaleric acid ester/l of catalyst/h. Partic. methyl 5-formylvalerate is used, in soln. in methanol.