RECOMBINANT TRANSFERRINS, TRANSFERRIN HALF-MOLECULES AND MUTANTS THEREOF
摘要
Recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functionnal form by stable eukaryotic cell lines such as baby hamster kidney cells transformed with an expression vector encoding the recombinant molecule. The recombinant transferrins can be used in metal chelation therapy to bind and clear excess toxic metals in patients suffering from metal overloads.
申请公布号
WO9213550(A1)
申请公布日期
1992.08.20
申请号
WO1992US00928
申请日期
1992.02.06
申请人
THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL C;UNIVERSITY OF BRITISH COLUMBIA
发明人
FUNK, WALTER, D.;MACGILLIVRAY, ROSS, T., A.;MASON, ANNE, B.;WOODWORTH, ROBERT, C.