METHOD FOR PRODUCTION OF FINELY DISPERSED TABLET COMPOSITION CONSISTING OF MICROCAPSULE CONTAINING SPRAYED AND DRIED SODIUM DICHLOFENAC AND HAVING ENTERIC COATING

摘要

PURPOSE: To provide a method for producing an enteric tablet dispersing microcapsules of diclofenac sodium with enteric coating. CONSTITUTION: This method for producing an enteric tablet comprises (a) a step for dissolving diclofenac sodium in a suitable amount of water, (b) a step for forming a suspension by adding an effective amount of vehicle to the obtained solution, (c) a step for forming a slurry by adding Eudargit L 30D and PEG 6000 as an enteric coating material to the obtained slurry, (d) a step for atomizing and spray-drying the obtained slurry to provide powder, (e) a step for mixing the spray-dried powder with a mixture of neocel and flostarch and (f) a step for forming the obtained powder mixture into a tablet to provide the objective enteric tablet. A microcapsule having enteric coating is produced by using an aqueous latex polymer dispersion such as Eudragit L 30D as an enteric coating polymer.