发明名称 |
(Aryl or heteroaromatic methyl)-2,2'-bi-hi-imidazoles and their use as anti-hypertensive agents |
摘要 |
This invention relates to novel (aryl or heteroaromatic methyl)-2,2 min -1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2 min -bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds. |
申请公布号 |
PH26551(A) |
申请公布日期 |
1992.08.19 |
申请号 |
PH20060000373 |
申请日期 |
1988.07.28 |
申请人 |
MERRELL DOW PHARMACEUTICALS, INC. |
发明人 |
DONALD P. MATTHEWS;JAMES R. MCCARTHY;JEFFREY P. WHITTEN |
分类号 |
A61K31/415;A61K31/425;A61P9/12;C07D233/54;C07D233/60;C07D233/64;C07D405/06;C07D405/14;C07D409/06;C07D409/14;C07D417/14 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|