| 摘要 |
<p>Novel pyrimidine derivatives and pharmacologically acceptable salts thereof are disclosed which exhibit excellent antitumor activity, and are represented by the following general formula: (I) wherein R1 represents a hydroxyl or amino group; R2 represents a phenylene, pyridinediyl, thiendiyl, furandiyl or thiazoldiyl group, -CO2R5 and -CO2R6 may be the same or different from each other and each represents a carboxyl group or a carboxylic acid ester, the part X-Y-Z represents , or , A represents an oxygen atom, a group represented by the formula: (wherein R3 and R4 may be the same or different from each other and each represents a hydrogen or halogen atom or a hydro-carbon group which may be substituted, or alternatively R3 and R4 may be united to form an alkylidene group which may be substituted) or a group represented by the formula: (wherein R70 represents a hydrogen atom or a hydrocarbon group), and n is an integer of 1 to 3, provided that the compound in which R1 represents oxygen, and hydrogen is attached to nitrogen at 3-position is included in the above shown definition. Processes for preparation of the derivatives (I) and their salts are also disclosed, as well as antitumor drugs containing the same.</p> |
