发明名称 |
Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof. |
摘要 |
<p>The present invention provides a method for resolving a mixture of optically active isomers of an alpha -amino acid to obtain the preferred optically active isomer. The mixture of isomers is contacted with at least one chiral resolving agent in an organic acid, which is at least a partial solvent for the alpha -amino acid, and in the presence of a mineral acid, which is present in a quantity which does not protonate the NH2 functionality of the alpha -amino acid to an extent that diastereomer interconversion is substantially prevented, and in the presence of a catalytic amount of an aromatic aldehyde. The contacting results in simultaneous resolution of a desired diastereomer and interconversion of the remaining undesired diastereomer, to provide a very high yield of the desired diastereomer having a very high optical purity. <IMAGE></p> |
申请公布号 |
EP0499376(A1) |
申请公布日期 |
1992.08.19 |
申请号 |
EP19920300648 |
申请日期 |
1992.01.24 |
申请人 |
HOECHST CELANESE CORPORATION |
发明人 |
BHATTACHARYA, APURBA;MOTT, GRAHAM N.;DURRWACHTER, JOHN R. |
分类号 |
C07B57/00;C07C227/34;C07C229/00;C07F9/30 |
主分类号 |
C07B57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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