| 摘要 |
PCT No. PCT/GB86/00481 Sec. 371 Date May 29, 1987 Sec. 102(e) Date May 29, 1987 PCT Filed Aug. 11, 1986 PCT Pub. No. WO87/00860 PCT Pub. Date Feb. 12, 1987.The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50 k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
|
