PROCESS OF TRANSFORMING MICROORGANISM TO OBTAIN ANTIHYPERTENSIVE PRODUT

摘要

Fermentation of the microorganism Actinoplanacete sp. in the presence of the Angiotensin II (A II) receptor antagonist yields a 5-hydroxymethyl and a 7-hydroxymethyl analog, both of which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.