发明名称 |
FACTOR STIMULATING GRANULAR CELL, RECOMBINANT DNA, RECOMBINANT VECTOR, PROCARYOTIC CELL, PREPARATION OF RECOMBINANT DNA, PREPARATION OF PROTEIN HAVING G-CSF ACTIVITY AND MEDICINAL PREPARATION CONTAINING G-CSF MUTANT PROTEIN |
摘要 |
<p>A granulocyte-stimulating factor (G-CSF) or G-CSF variant differs from natural G-CSF in that one or more amino acids in the sequence 50 51 52 53 54 55 56 Leu-Gly-His-Ser-Leu-Gly-Ile at position 50 to 56 of mature G-CSF with 174 amino acids or at position 53 to 59 of mature G-CSF with 177 amino acids and/or at least one of the 4 His residues at position 43, 79, 156 or 170 of mature G-CSF with 174 amino acids or at position 46, 82, 159 or 173 of mature G-CSF with 177 amino acids are mutated. It is suitable for immunotherapy.</p> |
申请公布号 |
JPH04225998(A) |
申请公布日期 |
1992.08.14 |
申请号 |
JP19910100666 |
申请日期 |
1991.05.02 |
申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
GIYUNTAA SHIYUUMATSUHAA;KAROORA DONII |
分类号 |
A61K38/00;A61P37/04;B23K26/351;C07K14/52;C07K14/53;C07K14/535;C12N1/21;C12N15/09;C12N15/27;C12N15/31;C12P21/02;C12R1/19 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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