| 摘要 |
The compounds of the invention are beta -amino- alpha -hydroxycarboxylic acid derivatives having the formula (I): <CHEM> wherein: R<1> represents a group of formula R(Z)xA- wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula -NR<a>R<b> wherein R<a> and R<b> are hydrogen atoms, alkyl groups, unsubstituted or substituted cycloalkyl, heterocyclic, aralkenyl or aryl groups, Z represents oxygen or sulphur; A represents a group of formula -CO-, -COCO-, -SO-, -SO2- or -CS-; and x is the cipher 0 or the integer 1; R<2> represents a hydrogen atom, or a substituted or unsubstituted alkyl group; R<3> is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; R<4> is a hydrogen atom, a substituted or unsubstituted alkyl, aryl or heterocyclic group; and R<5> represents a group of formula -B-(CO)-Y-Rc_y , wherein B represents a heterocyclic group unsubstituted or substituted with at least one alkyl group; Y represents an oxygen atom, a nitrogen atom or a sulphur atom; y is the integer 1 when Y represents an oxygen atom or a sulphur atom, and 2 when Y represents a nitrogen atom; and R<c> represents is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; and, where there are two groups or atoms represented by R<c>, they are the same or different; and and pharmaceutically acceptable salts and esters thereof. |
