| 摘要 |
<p>A process for preparing a drug-containing emulsion, comprising the steps of (a) optionally dissolving the drug in a suitable co-solvent, (b) mixing the drug or a solution thereof in the co-solvent with an aqueous preparation of a surfactant, (c) removing at least most of any co-solvent which is present, (d) mixing the product of step (c) with oil, and (e) forming an oil-in-water emulsion from the product of step (d). The drug is located in the surfactant layer of the resulting emulsion. The drug is preferably a polyene antifungal compound such as amphotericin B. The emsulsions are stable and reduce the toxicity of the drug.</p> |
