N-tetrazolyl beta-lactams

摘要

N-tetrazolyl beta-lactams of the Formula: <IMAGE> and the pharmaceutically acceptable salts thereof wherein R2 is hydrogen, alkyl having 1 to 6 carbon atoms or carboalkoxy having 2 to 7 carbon atoms; and Z is <IMAGE> and W is <IMAGE> thus forming a zwitterion, or Z is <IMAGE> wherein R1 is benzyl, phenyloxymethyl or <IMAGE> wherein Y is alkoxy or substituted alkoxy having 1 to 6 carbon atoms wherein the substituent on the alkoxy group is -COOH; and W is <IMAGE> wherein R3 is H, M or -CH2COOM, wherein M is a pharmaceutically acceptable cation are disclosed. The compounds are useful as antibiotics.