CYCLOPEPTIDE DERIVATIVES USABLE AS SELECTIVE INHIBITORS WITH RESPECT TO PROTEASES WITH ACTIVE SERINE

摘要

The invention relates to cyclopeptide derivative usable as protease inhibitors and complying with formula: <IMAGE> (I) in which R1 is a halogen atom, e.g. bromine or a radical such as S+R24X1/vv-, R2 is a hydrogen atom, an alkyl radical, a halogen atom or other groups, R3 is NH, O or S, Z comprises a peptide sequence Z1 and a group such that CO has one end connected to the aromatic nucleus and CO-AA is a radical derived fropm an amino acid having a specificity with respect to the protease to be inhibited.