METHOD FOR PREPARATION OF PYROXYCAM-CYCLODEXTRIN COMPOSITE, PRODUCT OBTAINED THEREBY AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

PURPOSE: To provide the subject complex having excellent technical characteristics, physical characteristics and biopharmacological characteristics in comparison with conventional liquid complexes and suitable for preparing pharmaceutical compositions for oral, rectal and topical uses. CONSTITUTION: This method for preparing a piroxicam-cyclodextrin complex comprises preliminarily mixing piroxicam and a cyclodextrin together in a solid powdery state and subsequently co-grinding the mixture in a high energy mill in the presence of steam.