| 摘要 |
PURPOSE:To obtain the subject new compound, useful as an antimicrobial agent, an antitumor agent and a therapeutic agent for AIDS, capable of exhibiting excellent antimicrobial action even on clinically separated germs and having high safety without any spastic inducing action by use with an anti-inflammatory agent together. CONSTITUTION:A compound expressed by formula I (R<1> is H or lower alkyl; R is F or Cl; R<3> is H, lower alkanoyl, etc.; carbon atoms with the asterisk marks * are asymmetric carbon atoms having R or S absolute configuration) and its salt, e.g. (1S,3'S)-7-(3-amino-1-pyrrolidinyl)-6,8-difluoro-1-methyl-4-oxo-1H,4 H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid. The aforementioned compound is obtained by condensing, e.g. a 7-halogenothiazetoquinoline-3-carboxylic acid derivative expressed by formula II with a 3-aminopyrrolidine derivative expressed by formula III, providing a diastereomer mixture of the compound expressed by formula I and then resolving the above-mentioned mixture by fractionation, recrystallization, etc. |
