VERFAHREN ZUR HERSTELLUNG VON FESTEN PHARMAZEUTISCHEN FORMEN.

摘要

Prodn. of solid pharmaceutical dosage forms is effected by mixing at least one active ingredient with at least one meltable binder andopt. other additives, and either injection moulding or extruding and shaping the mxit. at 50-180 deg.C.. The binder is a solvent free polymer of N-vinylpyrrolidone (NVP) comprising 20-100 wt.% NVP and 0-80 wt.% of N- and/or O-contg. comonomers. The polymer contains no more than 3.5 wt.% H2O.At least when the mxit. has a glass temp. above 130 deg.C, the polymer must be produced by polymerisation in an organic solvent or by polymerisation in an aq. medium using an organic peroxide initiator. The mixt. contains no added thermoplasts which are sparingly soluble in gastric juices.