WIRKSTOFFKOMBINATION ENTHALTEND DILTIAZEM UND ACETYLSALICYLSAEURE, DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN MIT EINER DIE THROMBOZYTEN-AGGREGATION HEMMENDEN WIRKUNG.

摘要

Combinations of acetylsalicylic acid (I) and dilitiazem (II) or its acid-addn. salts, including diltiazem acetylsalicylate, are new. A dosage unit comprises 10-300 mg. of (I) and 60-180 mg of (II). Diltiazem acetylsalicylate is prepd. by reacting (I) with an equimolar amt. of (II) in a solvent and freeze drying the resulting soln.