VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEN BICYCLO (3.3.0) OCTANDIONCARBONSAEUREESTERN.

摘要

Prodn. of optically active bicyclo(3,30)octane-dione carboxylates of formula (I) comprises enantioselective enzymatic hydrolysis and decarboxylation of the prochiral diester (II). Where R1 and R2 are together O or -O-X-O-, or individually are OR4; X = 1-7C alkylene; R4 = 1-7C alkyl; R3 = 1-10C alkyl. More specifically, reaction is with alpha-chymotrypsin (AC).