NUCLEIC ACID ENCODING INSULIN RECEPTOR SUBSTRATE-1 (IRS-1), IRS-1 PROTEIN, DISEASES, THERAPY ASSOCIATED WITH THE METABOLISM OF IRS-1

摘要

A purified nucleic acid consisting essentially of nucleic acid encoding IRS-1, Insulin Receptor Substrate-1; a purified polypeptide preparation of IRS-1; diagnosing an insulin-related disease comprising measuring an aspect of IRS-1 metabolism; diagnosing an insulin-related disease in a patient comprising determining the structure of the gene IRS-1; assaying an effect of a therapeutic agent which alters the ability of a tyrosine kinase to phosphorylate a substrate; a method of treating mammal suffering from a disease caused by IRS-1 metabolism; treating a mammal suffering from a disease caused by the phosphorylation of a substrate of a tyrosine kinase.