| 发明名称 |
New process for producing FK-506. |
| 摘要 |
<p>Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.</p> |
| 申请公布号 |
EP0497515(A1) |
申请公布日期 |
1992.08.05 |
| 申请号 |
EP19920300624 |
申请日期 |
1992.01.24 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
SALITURO, GINO M.;HUANG, LEEYUAN;DUMONT, FRANCIS;JONES, E. TRACY T.;GARRITY, GEORGE M.;OMSTEAD, MARY NALLIN;FERNANDEZ, ISABEL MARTIN;MATAS, TERESA DIEZ |
| 分类号 |
A61K31/435;A61P37/06;C07D498/18;C12N1/20;C12P17/18;C12P19/44;C12R1/325;C12R1/465 |
主分类号 |
A61K31/435 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
