TNF-inhibitory protein and a method of production

摘要

A TNF-inhibitory protein having a molecular weight of 28 kilodaltons and having an activity of rendering resistant to TNF a TNF- sensitive cell to thereby inhibit the cytolytic and/or cytostatic activity of TNF for the TNF-sensitive cells and a method for producing the same are described. The TNF-inhibitory protein can advantageously be used as an antigen for producing an antibody useful for detecting a patient having TNF-resistant cancer and for removing the TNF-resistance of the cancer cells of the patient.