发明名称 |
2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE |
摘要 |
The invention relates to new 2-hydroxy-n-propylamines of the formula R1-O-CH2-CHOH-CH2-NH-A-R2 (I) wherein R1, R2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and beta -blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.
|
申请公布号 |
US5135932(A) |
申请公布日期 |
1992.08.04 |
申请号 |
US19900530958 |
申请日期 |
1990.05.30 |
申请人 |
DR. KARL THOMAE GMBH |
发明人 |
HAUEL, NORBERT;MAUZ, ANNEROSE;VAN MEEL, JACQUES;ENTZEROTH, MICHAEL;ZIMMERMANN, RAINER;DIEDEREN, WILLI |
分类号 |
A61K31/50;A61P9/00;A61P9/10;A61P9/12;C07D237/04;C07D237/14;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D405/12;C07D413/04 |
主分类号 |
A61K31/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|