| 摘要 |
PURPOSE:To provide an artificial blood vessel rich in patency applicable for a fine-diameter artificial blood vessel by comprising it of a blood vessel derived from an animal having a watersoluble high polymer immobilized on an internal surface thereof by covalent bond. CONSTITUTION:A water soluble high polymer is immobilized on an internal surface of an animal blood vessel by a covalent bond. The type of the animal herein used is not limited specifically but mammal such as swine, dog, goat, bovine or sheep is appropriate. An artificial blood vessel having various diameters from 1mm to about 30mmm in inner diameter can be produced according to the type of animal or a sampling part of a blood vessel. To cause reaction with a carboxylic group of the blood vessel, a hydrophilic high polymer having an amino group is used and a crosslinking agent such as watersoluble carbodiimide or dialdehyde is used to accomplish the covalent bonding. Such a method is used preferably and when polyethylene oxide is used as one of watersoluble polymers, polymerization of ethylene exceeds preferably a certain degree and the number of polyethylene oxide units is 5 or more and preferably 15 or more. |
