发明名称 |
FAT EMULSION. |
摘要 |
A fat emulsion developed to solve the problems of polyene antifungal antibiotics that they have such a severe toxicity as to limit the administration range thereof by suitably designing the administration form, thereby reducing the hemolytic toxicity and nephrotoxicity and facilitating the migration of a drug toward infected parts without adversely affecting the pharmacological action (antifungal action) on a molecular level. The emulsion comprises 0.005 to 5 % of a polyene antifungal antibiotic, 0.5 to 30 % of a simple lipid, and a phospholipid in an amount 0.15 to 2 times as large as that of the simple lipid, wherein the relative proportion of each ingredient is controlled to give a fine microemulsion of a mean particle diameter of at least 10 nm up to 100 nm. This emulsion can remarkably enhance the efficacy of polyene antifungal antibiotics such as Amphotericin B and is very useful for the development of medicines. |
申请公布号 |
EP0598116(A4) |
申请公布日期 |
1992.07.30 |
申请号 |
EP19900917270 |
申请日期 |
1990.11.26 |
申请人 |
NIPPON SHINYAKU COMPANY, LIMITED |
发明人 |
SEKI, JUNZO;USHIMARU, KOUICHI;SUGIYAMA, MAKOTO |
分类号 |
A61K9/107;(IPC1-7):A61K9/107;A61K31/71 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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