发明名称 |
FREMGANGSMAATE FOR ENZYMATISK SPALTING AV REKOMBINANTE PROTEINER UNDER ANVENDELSE AV IGA-PROTEASER |
摘要 |
For the enzymatic cleavage of fused proteins and obtaining of desired portions of these fused proteins, (1) genetic engineering means are used to modify a junction region in which two portions of the fused protein are connected together so that in this junction region at least one IgA protease recognition site with the amino-acid sequence Y-Pro.< &darr& >.X-Pro is produced, where X can be any amino acid and Y can be any one or more amino acids, (2) the fused protein resulting from step (1) is cleaved by IgA protease at the position identified by .< &darr& >. in the recognition site and (3) after the cleavage one or more desired portions of the fused protein are obtained. |
申请公布号 |
NO923010(D0) |
申请公布日期 |
1992.07.30 |
申请号 |
NO19920003010 |
申请日期 |
1992.07.30 |
申请人 |
MAX-PLANCK-GES ZUR FOERDERUNG DER WISSENSCHAFTEN EV |
发明人 |
MEYER, THOMAS F.;POHLNER, JOHANNES;SCHUMACHER, GUENTER;DONY, CAROLA |
分类号 |
A61K38/00;A61K38/18;A61P37/04;C07K14/00;C07K14/28;C07K14/52;C07K14/53;C07K14/535;C07K14/54;C07K14/55;C07K14/705;C07K19/00;C12N1/19;C12N1/21;C12N9/12;C12N9/52;C12N15/09;C12N15/57;C12N15/62;C12N15/70;C12P21/02;C12P21/06;C12R1/19;C12R1/42 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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