A METHOD FOR THE PREPARATION IN A NON-RACEMIC FORM OF FURO (3,4-C) PYRIDINE DERIVATIVES

摘要

A method for resolving racemic mixtures of compounds having the formula or a pharmaceutically acceptable salt thereof that includes the steps of reacting the OR3 group of either compound with an esterifying agent in the case where R3 is H or a lower alkyl group; sujecting the compound to the action of an esterase capable of preferentially hydrolyzing either the (+) or (-) enantiomeric form of the compound; and separating the unhydrolyzed compound from the hydrolyzed compound.