| 摘要 |
<p>PURPOSE:To produce an alkanesulfoneanilide derivative or salt thereof having antiphlogistic action and analgesic action from a new raw material, in reduced producing processes and good yield. CONSTITUTION:A new compound expressed by formula I (R<1> is lower alkyl; R<2> is CN, CONH2 or lower alkanoyl; X is halogen) or salt thereof is reacted with a compound expressed by formula II (R<3> and R<4> are halogen; A is O or S; M is H, alkali metal or Cu) or salt thereof in the presence of a copper-base catalyst and a base using an aromatic amine based solvent to directly provide a compound expressed by formula III or salt thereof in high yield without using a preliminary process required in a conventional method. Furthermore, the new above-mentioned raw material can be produced by reacting a compound expressed by formula IV, its reactive derivative of the amino group or salt thereof with a compound expressed by the formula R<1>SO2OH, its reactive derivative of the sulfonic acid group or salt thereof to give a compound expressed by formula V or salt thereof and then hologenating the compound expressed by formula V or salt thereof.</p> |
